Over the past several years, the world has faced a series of unprecedented challenges-public health crises, climate change, racial and socioeconomic tensions-that have intensified the ongoing epidemic of substance use and overdose. The Clinical Manual of Addiction Psychopharmacology, now in its third edition, asserts that substance misuse and addictive disorders, although complex in origin, are inherently treatable.

This new edition is rich in information and practical guidance tailored to today's addiction psychiatry and addiction medicine workforce. The volume is organized by substance class-such as nicotine and tobacco, alcohol, cannabis, opioids, stimulants, and hallucinogens-offering quick access to essential information. Expert contributors synthesize the latest scientific advancements in how these substances affect those who misuse them, as well as the psychopharmacological and neurobiological bases for available treatments.

This updated edition also features four new chapters: • Treatment of Substance Use Disorders: An examination of the pharmacotherapy of addictive disorders through a broader system-based and social lens• Behavioral Addictions: An exploration of emerging treatments for non-substance-related addictive disorders such as gambling disorder• Integrative Approaches to Addiction Treatment: A comprehensive review of treatment literature on nonstandard pharmacotherapies, including herbal supplements• Circuit-Based Interventions for Substance Use Disorders: A description of interventional approaches that include transcranial magnetic stimulation and deep brain stimulation

Other chapters have been updated to reflect the changing social and clinical landscape in which clinicians practice. Additionally, epidemiological review has been intentionally minimized throughout the manual to allow readers to focus on the state of research and clinical treatment recommendations.

The Clinical Manual of Addiction Psychopharmacology, Third Edition, is a foundational, accessible resource for all those who seek to support the clinical needs of their patients and communities.

This revised manual is filled with the latest scientific advancements and practical guidance for today's addiction psychiatry and medicine workforce. New chapters in this volume discuss social and systemic perspectives on pharmacotherapy; emerging treatments for non-substance-related addictive disorders such as gambling; nonstandard pharmacotherapies, including herbal supplements; and interventional treatments such as transcranial magnetic stimulation.

PrefaceChapter 1. Treatment of Substance Use DisordersChapter 2. Nicotine and TobaccoChapter 3. Pharmacotherapy of Alcohol Use DisorderChapter 4. Cannabis and CannabinoidsChapter 5. OpioidsChapter 6. StimulantsChapter 7. Sedative-HypnoticsChapter 8. Hallucinogens and PhencyclidineChapter 9. Club Drugs and InhalantsChapter 10. Behavioral AddictionsChapter 11. Integrative Medicine Approaches to Addiction TreatmentChapter 12. Circuit-Based Interventions for Substance Use DisordersIndex

Jeffrey DeVido, M.D., M.T.S., is Assistant Clinical Professor-Volunteer at the Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences and University of California in San Francisco; Chief of Addiction Services of the Marin County, California, Department of Health and Human Services, Behavioral Health and Recovery Services Division; Behavioral Health Clinical Director at Partnership HealthPlan of California in Fairfield, California; and Staff Psychiatrist at the Mind Therapy Clinic in Corte Madera, California.

Carla Marienfeld, M.D., is Clinical Professor and Addiction Psychiatry Fellowship Director in the Department of Psychiatry at the University of California in San Diego.

Henry R. Kranzler, M.D., is Professor of Psychiatry and Director of the Center for Studies of Addiction at the University of Pennsylvania's Perelman School of Medicine in Philadelphia.

Petros Levounis, M.D., M.A., is Professor and Chair of the Department of Psychiatry and Associate Dean for Professional Development at Rutgers New Jersey Medical School and Chief of Service at University Hospital in Newark, New Jersey.